Table 1: Combined Sequential Hormone Replacement Therapy
Table 2: Estrogen Preparations
Table 3: Progestogen-only Preparations
Although not all of these progestogens are licensed for HRT, they may be tailored to suit individual patients.
| Preparation | Route of Administration | Formula | Dosage | Description |
|---|---|---|---|---|
| Utovlan | Oral | Norethisterone (2.5mg) | ||
| Micronor (pop) | Oral | Norethisterone (0.35mg) | 0.7-1.05mg | 2-3 tablets daily for 12 days of each cycle |
| Microval (pop) | Oral | Levonorgestrel (30µg) | 60-90µg | 2-3 tablets daily for 12 days of each cycle |
| Neogest (pop) | Oral | Norgestrel (75µg) | 150-225µg | 2-3 tablets daily for 12 days of each cycle |
| Norgeston (pop) | Oral | Levonorgestrel (30µg) | 60-90µg | 2-3 tablets daily for 12 days of each cycle |
| Noriday (pop) | Oral | Norethisterone (0.35mg) | 0.7-1.05mg | 2-3 tablets daily for 12 days of each cycle |
| Cyclogest | Vaginal suppository | Progesterone (200mg, 400mg) | 400mg | Daily for 12 days of each cycle |
| Crinone removed Utrogestan | Oral | Progesterone | 100mg, 200mg | For 12-14 days each cycle |
| Mirena IUS | IUS | Levonorgestrel (20mcg in 24hrs) | Licensed for 4 years with unopposed |
Table 4: Period-free therapy
| Type | Brand | Formulation | Estrogen | Progestogen |
|---|---|---|---|---|
| Continuous | Angeliq | Tablets | Estradiol (1mg) | Drospirenone (2mg) |
| Climesse | Tablets | Estradiol Valerate (2mg) | Norethisterone (0.7mg) | |
| Combined | Elleste Duet Conti | Tablets | Estradiol (2mg) | Norethisterone (1mg) |
| Kliovance | Tablets | Estradiol (1mg) | Norethisterone (0.5mg) | |
| Therapy | Kliofen | Tablets | Estradiol (2mg) | Norethisterone Acetate (1mg) |
| Premique | Tablets | Conj. Estrogens (0.625mg) | Medroxyprogesterone Acetate (5mg) | |
| Premique Low Dose | Tablets | Conj. Estrogens (0.3mg) | Medroxyprogesterone (1.5mg) | |
| Evorel Conti | Patches | Estradiol (50µg) | Norethisterone Acetate (170µg) | |
| Femseven Conti | Patches | Estradiol (50µg) | Levonorgestrel (10mcg) | |
| Nuvelle Continuous | Tablets | Estradiol (2mg) | Norethisterone Acetate (1mg) | |
| Femoston Conti | Tablets | Estradiol (1mg) | Dydrogesterone (5mg) | |
| Livial | Tablets | Tibolone (2.5mg) | Medroxyprogesterone Acetate (2.5mg) | |
| Indivina | Tablets | Estradiol Valerate (1mg) | Medroxyprogesterone Acetate (5mg) | |
| Tablets | Estradiol Valerate (2mg) | Medroxyprogesterone (5mg) |
Or separate combination of an estrogen (Table 2) and progestogen (Table 3)
Table 5: Vaginal natural estrogen preparations
| Brand | Formulation | Estrogen |
|---|---|---|
| Estring | Vaginal ring | Estradiol (7.5mcg) |
| Ortho-Gynest | Pessary, vaginal cream | Estriol (500mcg) |
| Ovestin | Vaginal cream | Estriol (0.1%) |
| Vagifem | Vaginal tablet | Estradiol (25mcg) |